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The great structural diversity
displayed by peptides allows the tailored production of biofunctionalized surfaces
e.g. for cellular biosensors. Peptides can be fixed covalently to surfaces by electropolymerisation, photo-crosslinking
and thiol-gold attachment.
This can also be done on defined microstructures that can be analysed by spectroscopic methods,
by ELISA and by bio-assays. Matrix assisted bilayer membranes capable of incorporating
membrane proteins are being developed with the aid of lipopeptides.
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1. W.Beck, J.Metzger, K.-H. Wiesmüller, and G. Jung (1992).
Immunosensors on the Basis of Lipopeptides (Part of ''Biosensors Based on Receptors'', by F. Jähnig,
G. Jung, G. Gauglitz, and W. Göpel),
in:
F. Scheller and R. D. Schmid (eds.), Biosensors: Fundamentals,
Technologies and Applications, GBF Monographs, Vol.17, pp.163-186, VCH Verlagsgesellschaft, Weinheim.
2. W.Beck, G.Gauglitz, U.Heilig, and G.Jung (1992).
Spectral Monitoring of Antibody-Hapten Interactions at Liposomal Membranes, Fresenius,
J. Anal. Chem. 343, 97.
3. A.Brecht, G.Gauglitz, W.Beck, R.Spohn, and G.Jung (1993).
Spectral Interferometric Immunoassay with Synthetic Lipid-Anchored Polypeptide Antigens,
in:
R.A.Lieberman (ed.), SPIE Proceedings, Vol. 1796.
4. B. Fleckenstein, K.-H. Wiesmüller, M. Brich, and G. Jung (1994).
Novel Heterobifunctionalized Polystyrene-polyethylene Glycol Resin for Simultaneous Preparation of
Free and Immobilized Peptides and Biological Activity Detected by Confocal Microscopy,
Letters in Peptide Science 1, 117-126.
5. M. Knichel, P. Heiduschka, W. Beck, G. Jung, and W. Göpel (1995).
Utilisation of a Self-Assembled Peptide Monolayer for an Impedimetric Immunosensor,
Sensors &
Actuators B 28, 85-94.
6. K.-H. Wiesmüller, M. Brich, G. Jung, K. Sparbier, and P. Walden (1995).
Peptide Binding to MHC Class I Molecules Analyzed by Confocal Microscopy,
Eur. J. Cell Biol.
66, 389-393.
7. P. Heiduschka, W. Göpel, W. Beck, W. Kraas, S. Kienle, and G. Jung (1996)
Microstructured Peptide Functionalized Surfaces by Electrochemical Polymerization,
Chem. Eur. J. 2, 667-672.
8. J. Rickert, T. Weiss, W. Kraas, G. Jung, and W. Göpel (1996)
A New Affinity Biosensor: Self-Assembled Thiols as Selective Monolayer Coatings of
Quartz Crystal Microbalances
,
Biosensors and Bioelectronics 11, 591-598.
9. J. Rickert, P. Heiduschka, W. Beck, G. Jung, and W. Göpel (1996)
A ''Mixed'' Self-Assembled Monolayer for an Impedimetric Immunosensor
,
Biosens. & Bioelectron. 11, 757-768.
10. M. Boncheva, C. Duschl, W. Beck, G. Jung, H. Vogel (1996)
Formation and Characterization of Lipopeptide Layers at Interfaces for the Molecular Recognition
of Antibodies
,
Langmuir 12, 5636-5642.
cojinfo@uni-tuebingen.de(cojinfo@uni-tuebingen.de) - July 23, 1997